TO STAY AHEAD OF PROGRESSION IN RELAPSING MS—
LOOK FOR THESE SIGNS1
Do you have younger adult RMS patients with fewer relapses and accumulating disability?1,2
Or patients living with RMS for 10 years or more and showing increasing disability?1,2
THE FOLLOWING SIGNS MAY SHOW UP IN YOUR RMS PATIENTS SOONER THAN YOU THINK3,4*
Trouble with memory or concentration
Weakness or problems with ambulation
Numbness or loss of sensation
Problems with coordination
Difficulty with speech or swallowing
Other neurologic findings related to MS
*As measured by the EDSS.
SUBTLE CHANGES OVER TIME
Not only do symptoms vary from patient to patient, they can often be mistaken for
normal aging or issues unrelated to MS. Consider taking a closer look, as it could be
progression hidden in plain view5,6
SUBTLE CHANGES OVER TIME
Not only do symptoms vary from patient to patient, they can often be mistaken for normal aging or issues unrelated to MS. Consider taking a closer look, as it could be progression hidden in plain view5,6
IDENTIFYING PROGRESSION IN RELAPSING MS AND
IDENTIFYING PROGRESSION IN RELAPSING MS AND ACTIVE SPMS7
Both terms describe a patient with RMS still showing some level of disease activity, as defined by relapses or inflammatory activity measured in an MRI, while also experiencing signs of disability progression that cannot be directly attributed to relapses.7SEE HOW MAYZENT CAN
HELP YOUR PATIENTS
EDSS=Expanded Disability Status Scale; MOA=mechanism of action; MOD=mechanism of disease; MS=multiple sclerosis; RMS=relapsing MS; SPMS=secondary progressive MS.
References: 1. Mayzent [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; January 2021.
2. Kappos L, Bar-Or A, Cree BAC, et al; for the EXPAND Clinical Investigators. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. Lancet. 2018;391(10127):1263-1273.
3. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology. 1983;33(11):1444-1452.
4. Gross HJ, Watson C. Characteristics, burden of illness, and physical functioning of patients with relapsing-remitting and secondary progressive multiple sclerosis: a cross-sectional US survey. Neuropsychiatr Dis Treat. 2017;13:1349-1357.
5. Multiple Sclerosis: Just the Facts. National Multiple Sclerosis Society website. https://www.nationalmssociety.org/nationalmssociety/media/
msnationalfiles/brochures/brochure-just-the-facts.pdf. Published 2016. Updated 2018. Accessed July 24, 2020. 6. Other Conditions to Rule Out. National Multiple Sclerosis Society website. https://www.nationalmssociety.org/Symptoms-Diagnosis/Other-Conditions-to-Rule-Out. Accessed July 24, 2020. 7. Types of MS. National Multiple Sclerosis Society website. https://www.nationalmssociety.org/What-is-MS/Types-of-MS. Accessed November 29, 2020. 8. Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. Brain. 1989;112(pt 1):133-146.